Vitamins for tiredness and fatigue

Iron, vitamin B12, folate, vitamin C and magnesium each contribute to the reduction of tiredness and fatigue, if you are short of them.

By the Supplements UK editorial team. Last checked 9 October 2026. General information, not medical advice.

Short answer Iron, vitamin B12, folate, vitamin C and magnesium each contribute to the reduction of tiredness and fatigue, if you are short of them. Tiredness lasting more than a few weeks should be checked by a GP.

Why a blood test comes first

Tiredness has many causes: sleep, stress, anaemia, thyroid problems, diabetes and others. Supplements help only where a deficiency is the cause.

If your diet is limited

A standard multivitamin and mineral covers the nutrients above at everyday levels.

Keep exploring

Questions people ask

What should I know about vitamins for tiredness and fatigue?

Iron, vitamin B12, folate, vitamin C and magnesium each contribute to the reduction of tiredness and fatigue, if you are short of them.

Can I take this with medication?

Ask a pharmacist or GP first; some supplements interact with medicines.

Do supplements replace a balanced diet?

No. They are meant to add to a varied diet, not stand in for one.

Sources

Checked 9 October 2026.