Probiotics with antibiotics

There is some evidence that taking a probiotic during a course of antibiotics reduces the chance of antibiotic-associated diarrhoea.

By the Supplements UK editorial team. Last checked 9 October 2026. General information, not medical advice.

Short answer There is some evidence that taking a probiotic during a course of antibiotics reduces the chance of antibiotic-associated diarrhoea. Take it a few hours apart from the antibiotic.

Which ones

Trials most often used Lactobacillus rhamnosus GG and Saccharomyces boulardii.

Who should not

People with weakened immune systems or who are seriously ill should ask their doctor first.

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Questions people ask

What should I know about probiotics with antibiotics?

There is some evidence that taking a probiotic during a course of antibiotics reduces the chance of antibiotic-associated diarrhoea.

Can I take this with medication?

Ask a pharmacist or GP first; some supplements interact with medicines.

Do supplements replace a balanced diet?

No. They are meant to add to a varied diet, not stand in for one.

Sources

Checked 9 October 2026.